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Image Search Results
Journal: Pharmaceutics
Article Title: Design and Evaluation of Autophagy-Inducing Particles for the Treatment of Abnormal Lipid Accumulation
doi: 10.3390/pharmaceutics14071379
Figure Lengend Snippet: In vivo and organ DiR fluorescence imaging of genetically obese ob/ob mice following a single IV injection (120 µL) of soluble fluorophore or fluorescent particles (0.25% w/v ). ( a ) Autophagy-inducing fluorescent particles (NP DiR T-B) and plain fluorescent particles (NP DiR) accumulate in the liver over the course of 72 h. Images are representative of scans from 3–4 mice per group. ( b ) Quantification of whole-body fluorescence up to 72 h post a single IV injection. The percentage values reported are calculated from the 5 min timepoint, when the maximal fluorescence was observed, and are reported as mean ± s.e.m. Results were analyzed using one-way ANOVA followed by Sidak’s multiple comparison test, which revealed no significant difference between the NP DiR and the NP DiR T-B group for all timepoints. ( c , d ) Organ biodistribution of fluorescent NPs 24 h after a single intravenous (IV) injection in ob/ob mice. n = 3–4 mice per group. Ex vivo DiR fluorescence imaging on main organs (liver, spleen, pancreas and kidneys) ( c ) and quantification of DiR fluorescence ( d ). The percentage values reported are calculated from total organ fluorescence and presented as mean ± s.e.m ( d ).
Article Snippet: Mice were immediately injected in the retro-orbital vein with 120 µL of either
Techniques: In Vivo, Fluorescence, Imaging, IV Injection, Comparison, Ex Vivo